Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity
نویسندگان
چکیده
منابع مشابه
Netrin-1 and kidney injury. II. Netrin-1 is an early biomarker of acute kidney injury.
Acute kidney injury is an important complication in hospitalized patients often diagnosed late and associated with high mortality and morbidity. Although biomarkers for nephrotoxicity are available, they often lack sensitivity and specificity for detecting tubular injury. Netrin-1 is a laminin-like molecule highly expressed in many organs including kidney. To determine the value of netrin-1 as ...
متن کاملUrinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury.
Sensitive and specific biomarkers are needed to detect early kidney injury. The objective of the present work was to develop a sensitive quantitative urinary test to identify renal injury in the rodent to facilitate early assessment of pathophysiological influences and drug toxicity. Two mouse monoclonal antibodies were made against the purified ectodomain of kidney injury molecule-1 (Kim-1), a...
متن کاملUrinary kidney injury molecule-1 (Kim-1): a sensitive quantitative biomarker for early detection of kidney tubular injury
Sensitive and specific biomarkers are needed to detect early kidney injury. The objective of the present work was to develop a sensitive quantitative urinary test to identify renal injury in the rodent to facilitate early assessment of pathophysiological influence and drug toxicity. Two mouse monoclonal antibodies were made against the purified ectodomain of kidney injury molecule-1 (Kim-1) and...
متن کاملKidney injury molecule-1 is an early noninvasive indicator for donor brain death-induced injury prior to kidney transplantation.
With more marginal deceased donors affecting graft viability, there is a need for specific parameters to assess kidney graft quality at the time of organ procurement in the deceased donor. Recently, kidney injury molecule-1 (Kim-1) was described as an early biomarker of renal proximal tubular damage. We assessed Kim-1 in a small animal brain death model as an early and noninvasive marker for do...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2007
ISSN: 0085-2538
DOI: 10.1038/sj.ki.5002467